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Turoctocog Alfa Pegol

展商：Novo Nordisk

原产国/地区：丹麦

Truncated B-domain-modified FVIII • GlycoPEGylation of turoctocog alfa’s truncated, 21-aa B-domain leads to an extended circulatory half-life1,2 • Activation of N8-GP yields native FVIIIa2-5 • Formulation and manufacturing without animal or human proteins2

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N8-GP (turoctocog alfa pegol)
Truncated B-domain-modified FVIII

 

•       GlycoPEGylation of turoctocog alfa’s truncated, 21-aa B-domain leads to an extended circulatory half-life1,2

•       Activation of N8-GP yields native FVIIIa2-5

•       Formulation and manufacturing without animal or human proteins2

 

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aa, amino acid; FVIIIa, activated factor VIII; PEG, polyethylene glycol

1. Thim L, et al. Haemophilia 2010;16:349–59;

2. Tiede A, et al. J Thromb Haemost 2013;11:670–8;

3. Giangrande P et al. Thromb Haemost 2017;117:252–61;

4. Agersø H et al. Haemophilia 2012;18:941–7; 

5. Stennicke HR et al. Blood 2013;121:2108–16.